%0 Journal Article
%T Long-term survival for COPD patients receiving noninvasive ventilation for acute respiratory failure
%A Titlestad IL
%A Lassen AT
%A Vestbo J
%J International Journal of COPD
%D 2013
%I Dove Medical Press
%X Ingrid L Titlestad,1 Annmarie T Lassen,2 J rgen Vestbo1,3 1Department of Respiratory Medicine, 2Department of Emergency Medicine, Odense University Hospital, University of Southern Denmark, Odense, Denmark; 3Respiratory Research Group, Manchester Academic Health Sciences Centre, University Hospital South Manchester NHS Foundation Trust, University of Manchester, Manchester, UK Abstract: Implementation of noninvasive ventilation (NIV) as an add-on treatment has been routinely used in a non-intensive care setting since 2004 for patients with chronic obstructive pulmonary disease (COPD) and acute hypercapnic respiratory failure at a university hospital in Denmark. Although randomized controlled trials show lowered mortality rates in highly selected patients with acute exacerbation and respiratory failure, there are only few reports on long-term survival after receiving NIV. We present long-term all-cause mortality data from patients receiving NIV for the first time. Method: Data from medical records were retrospectively retrieved from all patients receiving NIV for the first time after being admitted acutely to an acute medical ward and further transfer to a respiratory ward with respiratory failure and a diagnosis of COPD in the period January 1, 2005 to December 31, 2007; patients were followed until January 2012. Demographic data collected included age, sex, diagnoses at discharge, and, when present, FEV1; a ˇ°not-to-intubateˇ± order was also registered when listed. Results: In total, 253 patients (143 female, 110 male) received NIV for the first time. The median age was 72 years (range 46¨C91 years). The 30-day mortality rate was 29.3%. The 5-year survival rate was 23.7%. Women showed a trend towards better survival than men (25.7% vs 19.2%, P = 0.25), and the trend was even more pronounced for patients with COPD. Conclusion: The mortality rate of patients receiving NIV is high, as expected in a real-life setting, but with a 5-year survival rate of 23.7% with a trend towards more female than male long-term survivors. Keywords: COPD, acute respiratory failure, NIV, long-term survival
%U http://www.dovepress.com/long-term-survival-for-copd-patients-receiving-noninvasive-ventilation-a12879