%0 Journal Article
%T Investigation of Interaction Between Flurbiprofen and Fatty Acid Crystals
%A Misra AK*1
%A Misra M1
%A Panpalia GM1
%A Dorle AK2
%J Archives of Pharmacy Practice
%D 2011
%I Archives of Global Professionals
%X Objectives: Interaction between flurbiprofen and saturatedfatty acids keeping in view their crystalline nature has beeninvestigated.Materials and Methods: Samples were prepared by coevaporationmethod. FTIR, DSC, XRD, Microscopy (Opticalmicroscopy, Scanning electron microscopy, Atomic forcemicroscopy) techniques were employed for study ofinteraction between drug and fatty acid.Results: FT-IR showed significant changes in the spectralpattern of coevaporates. Possibility of polymorphic changesand eutectic formation was completely ruled out. A betterprobe into interaction was obtained by microscopic techniquesespecially atomic force microscopy.Conclusions: XRD was unable to detect any interactionbetween drug and fatty acid. FT-IR study detected chemicalinteraction between flurbiprofen and fatty acids. Similarobservations were made by DSC study. This study has clearlydemonstrated interaction between flurbiprofen and fatty acidis physicochemical in nature.
%K AFM
%K DSC
%K FTIR
%K SEM
%K XRD
%K Interaction
%K Flurbiprofen
%K Saturated Fatty Acid.
%U http://www.archivepp.com/Default.aspx