%0 Journal Article
%T Evaluation of floating press-coated pulsatile release of Aceclofenac tablets. A solution for Rheumatoid athritis
%A PV Shinde
%J Asian Journal of Biomedical and Pharmaceutical Sciences
%D 2013
%I 
%X The objective of this study was to develop and evaluate of a floating press-coated pulsatile drug delivery system intended for treatment of early morning stiffness and symptomatic relief from pain in patients with rheumatoid arthritis with a distinct predetermined lag time of 8 h. Cores containing Aceclofenac as model drug were prepared by direct compression of different Sodium starch glycolate level CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and Aceclofenac as a model drug by using various proportion of polymers such Hydroxypropyl methylcellulose and Sodium bicarbonate floating layer is prepared. Fifteen formulations were prepared and formulation F15, F18, F22possessed good lag time 8 hr and showed pulsatile drug delivery pattern the tablets In- vitro evaluation tests. Results of this study indicated that by using floating-pulsatile release formulations are suitable to optimize pulsatile drug release formulation of Aceclofenac.
%K Floating-pulsatile release formulations
%K Aceclofenac.
%U http://www.jbiopharm.com/index.php/ajbps/article/view/197