%0 Journal Article
%T Nabumetone Solubility Prediction in Dioxane-Water Mixtures Using Extended Hildebrand Solubility Approach
%A Pavan B Rathi
%A Kirti V. Deshpande
%A Prabhakar S. Panzade
%A Jyotiranjan Roul
%J Asian Journal of Biomedical and Pharmaceutical Sciences
%D 2013
%I 
%X The extended Hildebrand solubility parameter approach is used to estimate the solubility of nabumetone in binary solvent systems. The solubility of nabumetone in various dioxane-water mixtures was analyzed in terms of solute-solvent interactions using a modified version of Hildebrand-Scatchard treatment for regular solutions. The solubility of nabumetone in the binary solvent, dioxane-water shows a bell-shaped profile with a solubility maximum well below the ideal solubility of the drug. This is attributed to solvation of the drug with the dioxane-water mixture, and indicates that the solute-solvent interaction energy is larger than the geometric mean (¦Ä1¦Ä2) of regular solution theory. The new approach provides an accurate prediction of solubility once the interaction energy (W) is obtained. In this case, the energy term is regressed against a polynomial in ¦Ä1 of the binary mixture. Quadratic, cubic, and quartic expressions of ¡®W¡¯ in terms of solvent solubility parameter were utilized for predicting the solubility of nabumetone in various dioxane-water mixtures. But from these three polynomial expressions, a quartic expression of ¡®W¡¯ in terms of solvent solubility parameter was found suitable for predicting the solubility and yields an error in mole fraction solubility of ~7.346%, a value approximating that of the experimentally determined solubility. Thus the method has potential usefulness in preformulation and formulation studies during which solubility prediction is important for drug design.
%K Dioxane
%K extended Hildebrand solubility approach
%K ideal solubility
%K interaction energy
%K nabumetone
%K regular solution theory
%K solubility parameter
%U http://www.jbiopharm.com/index.php/ajbps/article/view/185/169