%0 Journal Article
%T Development of pulsatile release of Aceclofenac tablets with swelling and rupturable layers of ethyl cellulose
%A Shinde PV.
%J Asian Journal of Biomedical and Pharmaceutical Sciences
%D 2013
%I 
%X The objective of this study was to develop and evaluate of Aceclofenactablets with swelling and rupturable layers of ethyl cellulose. A tablet systemconsisting Intended for treatment of early morning stiffness and symptomaticrelief from pain in patients with rheumatoid arthritis with a distinctpredetermined lag time of 6 h. Cores containing Aceclofenac as model drugwere prepared by direct compression of different Sodium starch glycolatelevel CT-1 to CT-4) 8 %, 4%, 2% & without disinegrant and were then coatedsequentially with an inner swelling layer containing a superdisintegrant(croscarmellose sodium) and an outer rupturable layer of ethylcellulose.Seven formulations were prepared and formulation F2 possessed good lagtime 6 hr and showed pulsatile drug delivery pattern the tablets In- vitroevaluation tests. Results of this study indicated that by using ethyl celluloseare suitable to optimize pulsatile drug release formulation of Aceclofenac
%K Rupturable coating Pulsatile delivery
%K Aceclofenac.
%U http://www.jbiopharm.com/index.php/ajbps/article/view/145