%0 Journal Article
%T Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation
%A Min Jung Lee
%A Minhee Jang
%A Hyuk-Sang Jung
%A Sung-Hoon Kim
%A Ik-Hyun Cho
%J Molecular Pain
%D 2012
%I BioMed Central
%R 10.1186/1744-8069-8-40
%X EP significantly decreased formalin-induced nociceptive behavior during phase II, the magnitude of paw edema, and the activation of c-Fos in L4-L5 spinal dorsal horn. EP also attenuated the phosphorylation of extracellular signal-regulated kinase (ERK) in the neurons of L4-L5 spinal dorsal horn after formalin injection. Interestingly, the i.t. administration of PD98059, an ERK upstream kinase (MEK) inhibitor, completely blocked the formalin-induced inflammatory nociceptive responses.These results demonstrate that EP may effectively inhibit formalin-induced inflammatory nociception via the inhibition of neuronal ERK phosphorylation in the spinal dorsal horn, indicating its therapeutic potential in suppressing acute inflammatory pain.
%K Ethyl pyruvate
%K Inflammatory nociception
%K c-Fos
%K Phospho-ERK
%K PD-98059
%U http://www.molecularpain.com/content/8/1/40/abstract