%0 Journal Article
%T Role of JNK isoforms in the development of neuropathic pain following sciatic nerve transection in the mouse
%A Giusi Manassero
%A Ivan E Repetto
%A Stefano Cobianchi
%A Valeria Valsecchi
%A Christophe Bonny
%A Ferdinando Rossi
%A Alessandro Vercelli
%J Molecular Pain
%D 2012
%I BioMed Central
%R 10.1186/1744-8069-8-39
%X Peripheral nerve injury produced pain¨Crelated behavior on the ipsilateral hindpaw, accompanied by an increase in the percentage of GAP43-immunoreactive (IR) neurons and a decrease in the percentage of CGRP-IR neurons in the lumbar DRGs. The JNK inhibitor, D-JNKI-1, successfully modulated the effects of the sciatic nerve transection. The onset of neuropathic pain was not prevented by the deletion of a single JNK isoform, leading us to conclude that all JNK isoforms collectively contribute to maintain neuropathy. Autotomy behavior, typically induced by sciatic nerve axotomy, was absent in both the JNK1 and JNK3 knockout mice.JNK signaling plays an important role in regulating pain threshold: the inhibition of all of the JNK isoforms prevents the onset of neuropathic pain, while the deletion of a single splice JNK isoform mitigates established sensory abnormalities. JNK inactivation also has an effect on axonal sprouting following peripheral nerve injury.
%K Neuropathic pain
%K Sciatic nerve transection
%K JNK isoforms
%K Knockout mice
%U http://www.molecularpain.com/content/8/1/39/abstract