%0 Journal Article
%T Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
%A Aaron Erdely
%A James M Antonini
%A Rebecca Salmen-Muniz
%A Angie Liston
%A Tracy Hulderman
%A Petia P Simeonova
%A Michael L Kashon
%A Shengqiao Li
%A Ja K Gu
%A Samuel Stone
%A Bean T Chen
%A David G Frazer
%A Patti C Zeidler-Erdely
%J Particle and Fibre Toxicology
%D 2012
%I BioMed Central
%R 10.1186/1743-8977-9-25
%X The novel finding was a dominant type I interferon signaling network with the transcription factor Irf7 as a central component maintained through 28£¿d. Remarkably, these effects showed consistency across all tissues indicating a systemic type I interferon response that was complemented by changes in serum proteins (decreased MMP-9, CRP and increased VCAM1, oncostatin M, IP-10). In addition, pulmonary expression of interferon ¦Á and ¦Â and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. Also, a canonical pathway indicated a coordinated response of multiple PRR and associated signaling molecules (Tlr7, Tlr2, Clec7a, Nlrp3, Myd88) to inhalation of GMA-SS.This methodological approach has the potential to identify consistent, prominent and/or novel pathways and provides insight into mechanisms that contribute to pulmonary and systemic effects following toxicant exposure.
%K Microarray
%K Welding
%K Interferon regulatory factor 7
%K Cardiovascular disease
%K Chromium
%K Biomarker
%K Pattern recognition receptor
%K Whole blood cell gene expression
%K Aorta
%K Inhalation
%U http://www.particleandfibretoxicology.com/content/9/1/25/abstract