%0 Journal Article
%T Metronidazole-induced toxicosis in dog 每 case report Intoxica  o por metronidazol em c o 每 relato de caso
%A Marta Cristina Thomas Heckler
%A Carla Cristina Machado Riani Costa
%A Hugo Riani Costa
%A Rog谷rio Martins Amorim
%J Semina : Ci那ncias Agr芍rias
%D 2012
%I Universidade Estadual de Londrina
%X Metronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose the problem as quickly as possible to institute an early treatment. O metronidazol 谷 um antibi車tico nitronidaz車lico usado na medicina veterin芍ria para o tratamento de uma variedade de doen as. A causa da neurotoxicidade pelo metronidazol ainda n o foi determinada. Relata-se o caso de um c o, f那mea, da ra a Teckel, de cinco anos de idade, com hist車rico de dorsoflex o da cauda, ataxia, rigidez de musculatura, dec迆bito, nistagmo vertical, apatia e anorexia, que estava sendo medicada h芍 sete dias com metronidazol em dose maior que a m芍xima recomendada, sendo que os sinais neurol車gicos iniciaram-se ap車s esse per赤odo. As altera  es neurol車gicas foram compat赤veis com disfun  o vestibular central causada pelo metronidazol, tais como ataxia e nistagmo vertical. Al谷m das altera  es neurol車gicas, o quadro de anorexia e apatia 谷 condizente com a administra  o de doses excessivas do f芍rmaco. O diagn車stico da intoxica  o por metronidazol 谷 baseado na hist車ria de administra  o de doses normais a aumentadas, nos sinais cl赤nicos e na resolu  o destes ap車s a suspens o da droga. Geralmente, o progn車stico 谷 favor芍vel ap車s a suspens o do medicamento e com o diagn車stico precoce. Alguns c es podem morrer
%K C es
%K Neurologia
%K Sistema nervoso
%K Toxicidade de drogas.
%U http://www.uel.br/revistas/uel/index.php/semagrarias/article/view/7355