%0 Journal Article
%T Effects of particulate matter on inflammatory markers in the general adult population
%A Dai-Hua Tsai
%A Nadia Amyai
%A Pedro Marques-Vidal
%A Jia-Lin Wang
%A Michael Riediker
%A Vincent Mooser
%A Fred Paccaud
%A Gerard Waeber
%A Peter Vollenweider
%A Murielle Bochud
%J Particle and Fibre Toxicology
%D 2012
%I BioMed Central
%R 10.1186/1743-8977-9-24
%X We used baseline data from the CoLaus Study including 6183 adult participants residing in Lausanne, Switzerland. We analyzed the association of short-term exposure to PM10 (on the day of examination visit) with continuous circulating serum levels of high-sensitive C-reactive protein (hs-CRP), interleukin 1-beta (IL-1¦Â), interleukin 6 (IL-6), and tumor-necrosis-factor alpha (TNF-¦Á) by robust linear regressions, controlling for potential confounding factors and assessing effect modification.In adjusted analyses, for every 10£¿¦Ìg/m3 elevation in PM10, IL-1£¿ increased by 0.034 (95£¿% confidence interval, 0.007-0.060) pg/mL, IL-6 by 0.036 (0.015-0.057) pg/mL, and TNF-¦Á by 0.024 (0.013-0.035) pg/mL, whereas no significant association was found with hs-CRP levels.Short-term exposure to PM10 was positively associated with higher levels of circulating IL-1£¿, IL-6 and TNF-¦Á in the adult general population. This positive association suggests a link between air pollution and cardiovascular risk, although further studies are needed to clarify the mechanistic pathway linking PM10 to cardiovascular risk.
%K High-sensitive C-reactive protein (hs-CRP)
%K Interleukin 1-beta (IL-1¦Â)
%K Interleukin 6 (IL-6)
%K Tumor-necrosis-factor alpha (TNF-¦Á)
%K Air pollution
%U http://www.particleandfibretoxicology.com/content/9/1/24/abstract