%0 Journal Article
%T Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases
%A Asena £¿i£¿dem Do£¿ramac£¿
%A Mehmet U£¿ur £¿nan
%A Esin Atik
%A Cumali G£¿k£¿e
%J Balkan Medical Journal
%D 2012
%I Aves Yayincilik
%X Scleredema is a rare connective tissue disorder that belongs to a group of scleroderma-like disorders. Although no known curative therapy exists, various specific treatments have been proposed in the literature. In this report, we describe five cases of scleredema partially treated with low-dose methotrexate therapy. All patients have diabetes mellitus type II. All patients were started on methotrexate 15 mg subcutaneously once weekly for 3 months. Biopsy specimens were taken from all patients and were examinated histologically before the treatment and after 3 months of treatment. All cases partially responded to low-dose methotrexate therapy. We believe that methotrexate therapy may be an alternative therapeutic options in scleredema in view of its efficacy.
%K Scleredema
%K low-dose methotrexate
%K diabetes mellitus
%U http://balkanmedicaljournal.org/text.php3?id=868