%0 Journal Article
%T Desarrollo y validaci車n de un m谷todo espectrofluorom谷trico para la determinaci車n de furosemida en formas farmac谷uticas s車lidas
%A Alexis Buitrago
%A Laura Calder車n
%A Andr谷s Le車n
%A Rosario Brunetto
%J Avances en Qu赤mica
%D 2010
%I Universidad de los Andes
%X The aims of this work is to develop and validate an alternative analytic method by spectrofluorometry for the quality control of Furosemide in solid pharmaceutical forms based on the native fluorescence of the molecule in acidic medium (竹Exc.= 280nm and 竹Emi.= 410nm). This method allows to determine Furosemide in a buffer solution of potassium chloride-hydrochloric acid 50 mM (pH 2.0) in a range of 1.45x10-7 to 1.51x10-5 mol L-1 (4.5 to 5000 ng mL-1), with an estimated detection limit of 4.84x10-8 -mol L-1 (1.5 ng mL-1). The proposed method offers, as competitive advantages comparing to the official method reported in the United States Pharmacopeia (USP 29), its simplicity, low cost and frequency of analysis, around 20 samples per hour
%K Furosemide
%K spectrofluorometric
%K solid pharmaceutical forms
%U http://www.saber.ula.ve/bitstream/123456789/31054/1/articulo2.pdf