%0 Journal Article
%T Thrombotic microangiopathy associated with use of interferon-beta
%A Olea T
%A Diaz-Mancebo R
%A Picazo ML
%A Martinez-Ara J
%J International Journal of Nephrology and Renovascular Disease
%D 2012
%I 
%X Teresa Olea,1 Raquel D¨ªaz-Mancebo,1 Maria-Luz Picazo,2 Jorge Mart¨ªnez-Ara,1 Angel Robles,3 Rafael Selgas,11Departments of Nephrology, 2Pathology, 3Internal Medicine, Hospital Universitario La Paz, Madrid, SpainAbstract: Interferon-beta is widely used for the treatment of relapsing multiple sclerosis. The drug is usually well tolerated, but autoimmune adverse effects, including kidney disease, have been reported. Only a few cases of hemolytic uremic syndrome-thrombotic microangiopathy associated interferon-alpha have been described so far, and even fewer with beta-interferon. We report a patient who developed thrombotic microangiopathy during treatment with interferon-beta and improved after discontinuation and steroid therapy. Complement cascade and antiphospholipid antibodies are investigated. The spectrum of renal diseases associated with interferon-beta treatment is also reviewed.Keywords: thrombotic microangiopathy hemolytic uremic syndrome, multiple sclerosis, interferon-beta
%U http://www.dovepress.com/thrombotic-microangiopathy-associated-with-use-of-interferon-beta-a10128