%0 Journal Article
%T Effect of heavy metals on iturin A production in Bacillus subtilis Biofilm
%A Mohammad Shahedur Rahman*
%A Umme Salma Zohora
%A Takashi Ano
%J Biomirror
%D 2011
%I 
%X Biofilm fermentation of Bacillus subtilis RB14 for production of iturin A was studied by supplementation of different heavy metals in the 24- well multiplates. Biofilm formation was observed different when heavy metals were used. Iturin A production was enhanced with Mn2+ supplementation by highly structured biofilm development whichshowed significant contrast to iturin A production in submergedfermentation where no effect of Mn2+ addition was observed. Stabilityof the biofilm was affected as early denaturation of the biofilm wasdetected with the increased concentrations of Mn2+. Supplementationof 0.5 mM of Mn2+ addition was found to be enough for the biofilmdevelopment and iturin A production enhancement.
%K Bacillus subtilis
%K Iturin A
%K Biofilm
%K Heavy metal
%U http://www.bmjournal.in/admin/photo/1362037230October4.pdf