%0 Journal Article
%T Sirtuins ¨C universal regulators of cell function
%A Kaidashev I. P.
%J Biopolymers and Cell
%D 2012
%I Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine
%X The silent information regulator (SIR) genes code for a highly conserved family of proteins from bacteria to mammals ¨C sirtuins. Sirtuins are NAD+-dependent protein deacetylases with diverse physiological functions relating to cell survival, inflammation, energy metabolism, cancer. They are a part of complicated biological response system that influences many other regulator molecules and pathways. Sirtuins respond in an epigenetic manner to a variety of environmental factors, such as: dietary, lifestyle, toxins, etc. The data on the importance of vitamin B3 in supporting the sirtuin enzyme activity and a role of nicotinamide in inhibiting this activity are summarized. This mode of regulation may be exploited to manipulate the sirtuins activity in the context of various pathological conditions.
%K sirtuins
%K deacetylase
%K epigenetics
%K ADP-ribosyltransferase
%K regulation
%U http://www.biopolymers.org.ua/archive/2012/02/ru/04.pdf