%0 Journal Article
%T Acute gastrointestinal and genitourinary toxicity of image-guided intensity modulated radiation therapy for prostate cancer using a daily water-filled endorectal balloon
%A Curtiland Deville
%A Stefan Both
%A Viet Bui
%A Wei-Ting Hwang
%A Kay-See Tan
%A Mattia Schaer
%A Zelig Tochner
%A Neha Vapiwala
%J Radiation Oncology
%D 2012
%I BioMed Central
%R 10.1186/1748-717x-7-76
%X The first 100 patients undergoing prostate and proximal seminal vesicle IG-IMRT with indexed-lumen 100£¿cc ERBH2O to 79.2£¿Gy in 1.8£¿Gy fractions at our institution from 12/2008- 12/2010 were assessed. Pretreatment characteristics, organ-at-risk dose volume histograms, and maximum GU and GI toxicities (CTCAE 3.0) were evaluated. Logistic regression models evaluated univariate association between toxicities and dosimetric parameters, and uni- and multivariate association between toxicities and pretreatment characteristics.Mean age was 68 (range 51¨C88). Thirty-two, 49, and 19 patients were low, intermediate, and high-risk, respectively; 40 received concurrent androgen deprivation. No grade 3 or greater toxicities were recorded. Maximum GI toxicity was grade 0, 1, and 2 in 69%, 23%, and 8%, respectively. Infield (defined as 1£¿cm above/below the CTV) rectal mean/median doses, D75, V30, and V40 and hemorrhoid history were associated with grade 2 GI toxicity (Ps£¿<£¿0.05). Maximum acute GU toxicity was grade 0, 1, and 2 for 17%, 41%, and 42% of patients, respectively. Infield bladder V20 (P£¿=£¿0.03) and pretreatment International Prostate Symptom Scale (IPSS) (P£¿=£¿0.003) were associated with grade 2 GU toxicity.Prostate IG-IMRT using a daily ERBH2O shows low rates of acute GI toxicity compared to previous reports of air-filled ERB IMRT when using stringent infield rectum constraints and comparable GU toxicities.
%K Rectal balloon
%K IMRT
%K Toxicity
%K Prostate cancer
%U http://www.ro-journal.com/content/7/1/76/abstract