%0 Journal Article
%T PREPARATION AND OPTIMIZATION OF SIMVASTATIN NANOPARTICLE FOR SOLUBILITY ENHANCEMENT AND IN- VIVO STUDY
%A Mukesh S Patil
%J International Journal of Pharmaceutical Research and Development
%D 2011
%I rtechnology
%X The aim of the present study was to prepare Simvastatin nanoparticles by nanoprecipitation method using a partially water-miscible solvents and the mutual saturation of the aqueous and organic phases prior to form a nanosuspention in order to reduce the initial thermodynamic instability of the nanoparticles. Because of the self-emulsifying properties of the methacrylic acid co-polymers, it was possible to prepare aqueous dispersions of colloidal size containing up to 30% w/v of Eudragit L100 using methanol as a water-miscible solvent with surfactant. Nanoparticles have become an important area of research in the field of drug delivery, because they have the ability to deliver a wide range of drugs to varying areas of the body for sustained periods of time. The nanoparticles have a higher surface-to-volume ratio as compared with bulk material, and therefore the dose and frequency of administration would be reduced hence increasing patient compliance.
%K Nanoparticles
%K Nanoprecipitation techniques
%K Simvastatin.
%U http://www.ijprd.com/Article_No_277_Feb_11_23.html