%0 Journal Article
%T OPTIMISATION AND CHARACETRISATION OF CHITOSAN MICROSPHERES OF ACECLOFENAC
%A M. Mothilal
%A M. Nagalakshmi
%A Swati P.S.
%A Damodharan N.
%J International Journal of Pharma Sciences and Research
%D 2012
%I KEJA Publications
%X Purpose: The purpose of this study was to optimize and characterize the controlled release microspheres of Aceclofenac using ¡°Box-Behnken experimental design¡±. The microspheres were prepared by using thenatural polymer chitosan in different ratios with glutraldehyde as the cross linking agent. Method: The microspheres were prepared by ionic cross linking technique. The microspheres were evaluated for particle size, drug content, drug loading efficiency, in vitro drug release surface morphology. Results and Conclusions: The particle size of the prepared microspheres was between 3 to 800¦Ìm in diameter. In conclusion NSAID controlled release delivery system utilizing natural polymer i.e; chitosan was successfully developed. Furtherparameters for dosage form designing can be identified for optimum formulation in terms of desirable long term stability and to study the therapeutic effects of these particles in vivo.
%K Aceclofenac
%K Chitosan
%K Box-Behnken experimental design
%K microspheres
%U http://www.ijpsr.info/docs/IJPSR12-03-02-007.pdf