%0 Journal Article
%T COLORIMETRIC ESTIMATION OF NITAZOXANIDE AND OFLOXACIN IN PHARMACEUTICAL DOSAGE FORM
%A Vidya Sagar
%J International Journal of Pharmaceutical Research and Development
%D 2011
%I rtechnology
%X A Simple, accurate, precise, rapid and economical methods were developed for the simultaneous estimation of Nitazoxanide and Ofloxacin in tablet dosage form. Combination therapy of Nitazoxanide and Ofloxacin launched by GLENMARK, Pharmaceuticals limited, Mumbai, for the treatment of diarrhea caused by susceptible organisms. The colorimetric method where the wavelengths selected for Quantitation was 486 nm (? max of Ofloxacin) and 747 nm (? max of Nitazoxanide). The proposed colorimetric methods obey Beer¡¯s Law in concentration range from 5-50 ¦Ìg/ml of OFL and 10-100 ¦Ìg/ml for NTZ respectively. The results of analysis have been validated statistically and by recovery studies. The Percentage label claim and Percentage recoveries estimated were close to 99.55% and 98.75% with low value of standard deviation.The proposed methods have been applied successfully to routine analysis of the cited drugs in pharmaceutical formulations with good accuracy and precision.
%K Nitazoxanide
%K Ofloxacin
%K colorimetric method.
%U http://www.ijprd.com/Article_No_298_Mar_11_19.html