%0 Journal Article
%T Development and validation of UV spectroscopy method for estimation of lacosamide in bulk and formulations
%A Ganji Ramanaiah
%A D. Ramachandran
%A G.Srinivas
%A Srilakshmi
%J International Journal of Pharmacy and Biomedical Sciences
%D 2012
%I 
%X A rapid and sensitive UV-Visible spectroscopic method was developed for the estimation of Lacosamide in bulk and its pharmaceutical formulation. The method was validated as per International Conference on Harmonization [ICH] guidelines. The Lacosamide was monitored at 230 nm with UV detection and there is no interference of diluent at 230 nm for lacosamide. The method was linear (r2=0.999) at concentration ranging from 12 to 40 ¦Ìg/mL, precise (intra and inter-day RSD values < 1.0%), accurate (mean recovery = 99.9%), specific and robust. The results showed that the proposed method is suitable for the precise, accurate and rapid determination of lacosamide in bulk and tablet dosage forms.
%K Lacosamide
%K UV-Visible spectroscopy
%K Validation
%K Dosage form
%U http://www.pharmainterscience.com/Docs/IJPBS-2012-03-31.pdf