%0 Journal Article
%T A prospective cohort study of the long-term effects of CPAP on carotid artery intima-media thickness in Obstructive sleep apnea syndrome
%A David S Hui
%A Qing Shang
%A Fanny W Ko
%A Susanna S Ng
%A Cheuk-Chun Szeto
%A Jenny Ngai
%A Alvin H Tung
%A Kin-Wang To
%A Tat-On Chan
%A Cheuk-Man Yu
%J Respiratory Research
%D 2012
%I BioMed Central
%R 10.1186/1465-9921-13-22
%X A prospective observational study over 12 months at a teaching hospital on 50 patients newly diagnosed with OSAS who received CPAP or conservative treatment (CT). Carotid IMT was assessed with B-mode Doppler ultrasound from both carotid arteries using images of the far wall of the distal 10 mm of the common carotid arteries at baseline, 6 months and 12 months.Altogether 28 and 22 patients received CPAP and CT respectively without significant differences in age 48.8(1.8) vs 50.5(2.0)yrs, BMI 28.2(0.7) vs 28.0(1.2)kg/m2, ESS 13.1(0.7) vs 12.7(0.6), AHI 38(3) vs 39(3)/hr, arousal index 29(2) vs 29(2)/hr, minimum SaO2 75(2) vs 77(2)% and existing co-morbidities. CPAP usage was 4.6(0.3) and 4.7(0.4)hrs/night over 6 months and 1 year respectively. Carotid artery IMT at baseline, 6 months, and 12 months were 758(30), 721(20), and 705(20)micron for the CPAP group versus 760(30), 770(30), and 778(30)micron respectively for the CT group, p = 0.002.Among those free of cardiovascular disease(n = 24), the carotid artery IMT at baseline, 6 months and 12 months were 722(40), 691(40), and 659(30)micron for the CPAP group (n = 12) with usage 4.5(0.7) and 4.7(0.7) hrs/night over 6 months and 12 months whereas the IMT data for the CT group(n = 12) were 660(20), 685(10), and 690(20)micron respectively, p = 0.006.Reduction of carotid artery IMT occurred mostly in the first 6 months and was sustained at 12 months in patients with reasonable CPAP compliance.Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction causing daytime sleepiness, impaired cognitive function and poor health status [1]. Untreated OSA is associated with increased risks of developing fatal and non-fatal cardiovascular events [2,3]. Three large prospective cohort studies have shown that untreated OSA is an independent risk factor for all-cause mortality after long-term follow-up [4-6]. Untreated OSA is also associated with dysglycemia, systemic inflammation, endothe
%U http://respiratory-research.com/content/13/1/22