%0 Journal Article
%T Development of Diclofenac Sodium-Loaded Alginate-PVP K 30 Microbeads Using Central Composite Design
%A AK Nayak
%A S Khatua
%A MS Hasnain
%A KK Sen
%J DARU : Journal of Pharmaceutical Sciences
%D 2011
%I BioMed Central
%X Background and the purpose of the study: Diclofenac sodium is a non-steroidal anti-inflammatory agent with a short biological half-life (1-2 hr) and requires multiple dosing. This research was carried out to develop and optimize diclofenac sodium loaded alginate-PVP K 30 microbeads to eliminate the need for multiple dosing and adverse effects. Methods: Diclofenac sodium loaded alginate-PVP K 30 microbeads were prepared by ionotropic gelation. Particle size, drug release, swelling, FTIR and SEM analyses were performed. Results: Optimized microbeads showed particle size of 0.589 ¡À 0.054 to 0.620 ¡À 0.067 mm, and drug entrapment efficiency of 97.88 ¡À 2.86 to 98.60 ¡À 3.55 %. The in vitro drug release from microbeads was sustained over 10 hrs and followed controlled-release pattern. FTIR analysis indicated the possibility of intermolecular hydrogen bonding interactions, i.e., -OH...O=C in microbeads. Conclusion: Microbeads for oral controlled delivery of diclofenac sodium were successfully developed by ionotropic gelation.
%K Controlled Release
%K Optimization
%K Lonotropic Gelation
%K Polymer Blend
%K FTIR
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19850.pdf&manuscript_id=19850