%0 Journal Article
%T Gastroprotective activity of ¦Á-terpineol in two experimental models of gastric ulcer in rats
%A RHL Souza
%A MSP Cardoso
%A CT Menezes
%A JP Silva
%J DARU : Journal of Pharmaceutical Sciences
%D 2011
%I BioMed Central
%X Background and the purpose of the study: Several plant essential oils, as well as terpenes present in essential oils, have shown gastroprotective activity. The aim of the present work was to evaluate the gastroprotective activity of ¦Á-terpineol, a monoterpene alcohol which is present in essential oils of various plants. Methods: The gastroprotective activity of ¦Á-terpineol was evaluated in rats by assessing the changes in ethanol and indomethacin-induced gastric ulcer scores and on gastric secretory volume and total acidity in pylorus-ligated rats. Alpha-terpineol was administrated orally at the doses of 10, 30, and 50 mg/kg one hour before administration of the ulcer inducing agents by the pylorus ligation procedure. The involvement of endogenous prostaglandins in the protective effect of ¦Á-terpineol in ethanol-induced gastric lesions test was assessed by administration of indomethacin (10 mg/kg, s.c.) 30 min before oral administration of ¦Á-terpineol at the dose of 50 mg/kg. Results: ¦Á-terpineol presented gastroprotective activity against ethanol-induced ulcers at the doses of 10, 30, and 50 mg/kg. Epoxy-carvone at the dose of 10 mg/kg did not present gastroprotective activity against ulcer induced by indomethacin, but at the doses of 30 and 50 mg/kg it attenuated the gastric damages induced by this agent significantly. Pretreatment with indomethacin did not prevent the gastroprotective effect of ¦Á-terpineol on ethanol-induced ulcers. Alpha-terpineol also did not affect the gastric secretion in pylorus-ligated rats. Major conclusion: The results suggest that ¦Á-terpineol presents gastroprotective action which does not involve either an increase in the synthesis of endogenous prostaglandin or a decrease in the gastric acid secretion.
%K Monoterpenes
%K Essential oils
%K Gastroprotection
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/19396.pdf&manuscript_id=19396