%0 Journal Article
%T Hypoxia-Inducible Factor-1¦Á: A Potential Factor for the Enhancement of Osseointegration between Dental Implants and Tissue-Engineered Bone
%A Duohong Zou
%A Siheng Zhu
%A Jian Zhou
%A Jian Zhou
%J Dental Hypotheses
%D 2011
%I Dental Hypotheses
%X Introduction: Tissue-engineered bones are widely utilized to protect healthy tissue, reduce pain, and increase the success rate of dental implants. one of the most challenging obstacles lies in obtaining effective os-seointegration between dental implants and tissue-engineered structures. Deficiencies in vascularization, osteogenic factors, oxygen, and other nutrients inside the tissue-engineered bone during the early stages following implantation all inhibit effective osseointe-gration. Oxygen is required for aerobic metabolism in bone and blood vessel tissues, but oxygen levels inside tissue-engineered bone are not suf-ficient for cell proliferation. HIF-1¦Á is a pivotal regulator of hypoxic and ischemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and osteogenesis.The hypothesis: Hypoxia-Inducible Factor-1¦Á seems a potential factor for the enhancement of osseointegration between dental implants and tissue-engineered bone.Evaluation of the hypothesis: Enhancement of HIF-1¦Á protein expression is recognized as the most promising approach for angiogenesis, because it can induce multiple angiogenic targets in a coordinated manner. Therefore, it will be a novel potential therapeutic methods targeting HIF-1¦Á expression to enhance osseointegration be-tween dental implants and tissue-engineered bone.
%K Hypoxia-inducible factor-1¦Á
%K Angiogenesis
%K Osteogenesis
%K Osseointegration
%K Dental implant
%K Tissue-engineered bone.
%U http://www.dentalhypotheses.com/index.php/dhj/article/view/47