%0 Journal Article
%T Effect of Ketoprofen Co-administration on Pharmacokinetic of Cefepime in Cow Calves
%A Patil AJ
%A SK Bhavsar1
%A HB Patel
%A NN Patel
%A SD Patel
%A S Dewda
%A JH Patel1* and Thaker AM
%J International Journal of Veterinary Science
%D 2012
%I Nnamdi Azikiwe University
%X The pharmacokinetic of cefepime (5 mg/kg) was studied following intramuscular administration of cefepime alone and co-administered with ketoprofen (3 mg/kg) in cow calves. The concentration of cefepime in serum was detected by using High Performance Liquid Chromatography. Following single dose intravenous administration of cefepime, elimination half life (3.90¡À0.08 h), area under curve (48.68¡À2.53 ¦Ìg.h/mL), body clearance (1.74¡À0.09 L/h/kg) and volume of distribution (0.52¡À0.03 L/kg) were determined. Following single dose intramuscular administration of cefepime alone, peak serum concentration (8.93¡À0.32 ¦Ìg/mL) was obtained at 45 h. The absorption half life (t1/2K¦Á), volume of distribution (Vdarea), total body clearance (ClB) and elimination half life (t1/2¦Â) of cefepime were 0.17¡À0.01 h, 0.79¡À0.05 L/kg, 1.76¡À0.10 L/h/kg and 5.15¡À0.09 h, respectively. No significant changes were reported in pharmacokinetic parameters following co-administration of cefepime with ketoprofen. Integration of pharmacokinetic data generated from the present study and minimum inhibitory concentration suggest that the cefepime can be administered intramuscularly (5 mg/kg) with ketoprofen at 12 h interval to combat susceptible bacterial infections in cow calves.
%K Cefepime
%K Cow Calves
%K Pharmacokinetic
%K Ketoprofen
%U http://www.ijvets.com/wp-content/uploads/pdf-files/Volume-1-Issue-2-2012/72-75.pdf