%0 Journal Article
%T Evaluation of Interleukin 1¦Â in Febrile Convulsion
%A Fatemeh Behmanesh
%A Farah Ashrafzadeh
%A Abdoreza Varasteh
%A Abdoreza Shakeri
%J Iranian Journal Of Allergy, Asthma and Immunology
%D 2012
%I Tehran University of Medical Sciences
%X We aimed to study the MnTnHex-2-PyP effect on some markers of lung antioxidant defence system in mice asthma model.The study was carried out on 28 C57B1/6 mice divided into four treatment groups: group 1 ¨C controls; group 2 ¨C injected and inhaled with ovalbumin; group 3 ¨C treated with MnTnHex-2-PyP and inhaled with phosphate buffered saline; group 4 ¨C injected with ovalbumin and MnTnHex-2-PyP but also inhaled with ovalbumin. On days 24, 25 and 26, mice from groups 1 and 2 were inhaled with PBS for 30 min, and those from groups 2 and 4 were given a 1% ovalbumin solution. One hour before inhalation, and 12 hours later the animals from groups 1 and 2 were injected i.p. with 100 ¦Ìl PBS, and those from groups 3 and 4 received a 100 ¦Ìl MnTnHex-2-PyP solution in PBS, §ãontaining 0,05mg/kg. The animals were killed by exsanguination 48 hours after the last inhalation for obtaining a lung homogenate.The activities of superoxide dismutase, catalase, glutathione peroxidase and the non-protein sulphhydryl group content in the lung homogenate were investigated. Ovalbumin decreased the activities of superoxide dismutase (p=0.01), catalase (p=0.002), glutathione peroxidase and non-protein sulphhydryl groups content (p<0.001) in comparison to controls. In group 4 (ovalbumin and MnTnHex-2-PyP) the activities of superoxide dismutase (p=0.044), catalase (p=0.045), glutathione peroxidase (p=0.002), and the non-protein sulphhydryl groups content (p<0.001) were significantly increased compared to ovalbumin (group 2).MnTnHex-2-PyP restored the activities of basic enzymes in the lung antioxidant defence system in ovalbumin-induced asthma mice model, 48 hours after the last nebulization.
%K Children
%K Febrile convulsion
%K Interleukin 1$
%U http://ijaai.tums.ac.ir/index.php/ijaai/article/view/554/404