%0 Journal Article
%T Recent perspectives on the role of microRNAs of the miR-15 family in liver disease
%A MA Lixia
%J Journal of Clinical Hepatology
%D 2013
%I Journal of Clinical Hepatology
%X Since their recent discovery, microRNAs (miRNAs), a class of short endogenous non-coding RNAs, have gained substantial research attention for their critical roles in a broad range of physiologic and pathogenic processes. Under normal physiological conditions, the miR-15 family members regulate several important cellular functions, including apoptosis, cell differentiation, cell cycle, and stress responses. However, under pathological conditions, the miR-15 family members contribute to carcinogenesis, cardiovascular dysfunctions, and neurodegeneration; these activities may represent potentially useful targets of molecular therapeutic strategies. In this review, we summarize and discuss the important functions and promising therapeutic applications of the miR-15 family in liver cancer, acute liver failure, liver fibrosis, and liver damage.
%K microRNAs
%K hepatitis
%K chronic
%K liver cirrhosis
%K liver failure
%K acute
%K carcinoma
%K hepatocellular
%U http://www.lcgdbzz.org/qk_content.asp?id=5256&ClassID=115155931