%0 Journal Article
%T Recent Advances on TRPA1 Channels
%A DENG Ke-xuan
%A HE Qi-yi
%A ZHOU Jia-li
%A YU Xiao-dong
%J Journal of Chongqing Normal University
%D 2013
%I Chongqing Normal University
%X The TRP (Transient receptor potential) ion channels are a large family of ion channels which located on the cell membrane.Based on their sequence homology£¬mammalian TRP ion channels can be divided into six subfamilies£ºTRPC£¬TRPM£¬TRPV£¬TRPA£¬TRPML£¬TRPP.TRP ion channels which are used as cell receptors can be activated and controlled by a variety of mechanisms.In this review£¬the studies on TRPA1 are summarized£¬and the ways how the TRPA1 are activated by a variety of mode are discussed£¬especially the role of TRPA1 as a receptor in animals responding to various physical and chemical stimulus signals.TRPA1 is a member of transient receptor potential protein (TRP) family.It is selectively expressed in hair and skin cells and in a subpopulation of neurons in the trigeminal£¬nodose ganglia and dorsal root.As well as other members of TRP£¬TRPA1 mediates many sensory physiological functions in animals.Current research gradually clear the role of TRPA1 ion channel in the cold sensation£¬thermo sensory£¬mechanical stimulation and pain perception in the organism by means of RNAi and gene knockout technology£¬this will significantly promote the study of the path physiological processes and mechanisms of sensory disorders.
%K TRPA1£»sensory physiology£»physical and chemical stimulus
%U http://journal.cqnu.edu.cn/1301/pdf/130108.pdf