%0 Journal Article
%T Riedel's thyroiditis - a case report with genes' expression studies
%A Katarzyna Wojciechowska-Durczy¨½ska
%A Adam Durczy¨½ski
%A Stanis£¿aw Sporny
%A Janusz Strzelczyk
%A Andrzej Lewi¨½ski
%J Thyroid Research
%D 2012
%I BioMed Central
%R 10.1186/1756-6614-5-2
%X We report the case of 48-year old woman with Riedel's thyroiditis who has presented unusual course of disease with non-specific cervical discomfort, though as with no pain and/or no compression symptoms. After surgery, thyroid specimens were quantitatively evaluated, regarding PIK3CA, PIK3CD, PIK3CG, Tg, TGFB1, THRB, COL1, CDKN1C, CDH3 and CACNA2D2 genes expression levels, by real-time PCR in the ABI PRISM£¿ 7500 Sequence Detection System. Out of 10 above genes, in 2 cases the expression was higher than in respective Controls of unchanged thyroid tissue. In the remaining 8 cases, expression in question became comparable or lower as in Controls.The association between increased expression levels of PIK3CA and CDH3 genes and Riedel's thyroiditis is not well-defined. However, the increased expression of PIK3CA and CDH3 genes in our case report and in previous studies of other authors on various malignancies may suggest possible molecular relation between Riedel's thyroiditis and certain neoplastic processes, the relation of which requires further genetic evaluation. It is to be stressed that gene expression studies in Riedel's thyroiditis are difficult to perform, mainly due to fibrosis, resulting in scarce thyroid specimens and - in consequence - small amount of genetic material.Riedel's thyroiditis is a rare fibrosclerotic infiltrative thyroid disorder of unclear etiology, during which normal thyroid tissues are replaced by fibrous tissue, often expanding outside the thyroid capsule. The diagnosis can be difficult to establish prior to surgical removal of the thyroid and to subsequent histopathological examination of the resected gland [1-3]. Reports on genetic findings in Riedel's thyroiditis are scarce in medical literature. Herein, we describe our results of studies on genes expression levels in Riedel's thyroiditis.We report the case of 48-year old women, diagnosed originally as a goiter with eminently increased consistency on palpation, presented with non-specifi
%K Riedel's thyroiditis
%K Genes' expression
%K Real-time PCR
%U http://www.thyroidresearchjournal.com/content/5/1/2