%0 Journal Article
%T Autoimmune encephalopathy associated with thyroid autoantibodies as the cause of reversible cognitive impairment
%A Natallia Maroz
%A Nechama Bernhardt
%A Robert Dobbin Chow
%J Journal of Community Hospital Internal Medicine Perspectives
%D 2012
%I Co-Action Publishing
%R 10.3402/jchimp.v2i1.11453
%X We herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH = 18.6 MIU/ml, T3reverse = 0.44nmol/L, T4 = 0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/ml. Based on the above findings the patient was diagnosed with Hashimoto's encephalopathy and his mental status showed dramatic improvement (MMS 30/30) with high dose prednisone. Hashimoto's encephalopathy is rare disorder of presumed autoimmune origin characterized by cognitive decline, seizures, neuro-psychiatric symptoms, high titers of Anti-Thyroid-Peroxidase AB, and a positive response to steroids.
%K hashimoto
%K reversible cognitive impairment
%K autoimmune encephalopathy
%K thyroid-peroxidase antibody
%U http://www.jchimp.net/index.php/jchimp/article/view/11453/pdf_1