%0 Journal Article
%T Expression pattern of protein kinase C ¦Ä during mouse embryogenesis
%A Carracedo Sergio
%A Braun Ursula
%A Leitges Michael
%J BMC Developmental Biology
%D 2013
%I BioMed Central
%R 10.1186/1471-213x-13-2
%X Background The members of the protein kinase C (PKC) family consist of serine/threonine kinases classified according to their regulatory domain. Those that belong to the novel PKC subfamily, such as PKC¦Ä, are dependent on diacylglycerol but not Calcium when considering their catalytic activity. Although several studies have shown the importance of PKC¦Ä in different cellular events in health and disease, the overall in vivo distribution of this PKC isoform during development is still lacking. Through Lac Z and antibody staining procedures, we show here the in vivo expression of PKC¦Ä during mouse embryogenesis. Results Ganglia were the domains with most prominent expression of PKC¦Ä in most of the stages analysed, although PKC¦Ä could also be detected in heart and somites at earlier stages, and cartilage primordium and skin among other sites in older embryos. Conclusions The strong expression of PKC¦Ä in ganglia during murine development shown in this study suggests a significant role of this isoform as well as redundancy with other PKCs within the nervous system, since PKC¦Ä deficient mice develop normally.
%K Novel protein kinase C
%K PKC delta
%K Mouse embryogenesis
%K Lac Z
%K Ganglia
%U http://www.biomedcentral.com/1471-213X/13/2