%0 Journal Article
%T The pharmacology and therapeutic potential of (-)-huperzine A
%A Tun MK
%A Herzon SB
%J Journal of Experimental Pharmacology
%D 2012
%I Dove Medical Press
%X Maung Kyaw Moe Tun, Seth B HerzonDepartment of Chemistry, Yale University, New Haven, CT, USAAbstract: (¨C)-Huperzine A (1) is an alkaloid isolated from a Chinese club moss. Due to its potent neuroprotective activities, it has been investigated as a candidate for the treatment of neurodegenerative diseases, including Alzheimer's disease. In this review, we will discuss the pharmacology and therapeutic potential of (¨C)-huperzine A (1). Synthetic studies of (¨C)-huperzine A (1) aimed at enabling its development as a pharmaceutical will be described.Keywords: Alzheimer's, NMDA, neurodegeneration, natural products, synthesis
%U http://www.dovepress.com/the-pharmacology-and-therapeutic-potential-of---huperzine-a-a10927