%0 Journal Article
%T DERIVADOS DEL 2-FURILETILENO INDUCEN LA MUERTE CELULAR PROGRAMADA EN C¨¦LULAS CHO DE MAM¨ªFERO
%A Hern¨¢ndez OC
%A Pimentel H
%A Llanes LL
%A Fern¨¢ndez S
%J Electronic Journal of Biomedicine
%D 2012
%I Asociaci¨®n Red Uninet
%X Aim: to evaluate the morphological and physiological changes induced by the synthesized products G1 and UC245 and the apoptotic process using CHO cell culture. Material and Methods: the Ca2+ uptake, DNA fragmentation in 1,8% agarose gel electrophoresis, nuclear morphology and mitotic index were studied as evidence of programated death cell. Results: the cytosolic Ca2+ increase and DNA fragmentation observed in association with nuclear morphology changes were consistent as molecular mark of apoptosis induced by the 2-furylethylene derivatives studied. Conclusions: these two synthesized products could confirm an inductor effect on apoptotic mechanism of this cell line.
%K Bromine. Apoptosis. Furylethylene. DNA fragmentation. CHO. Mitotic index
%U http://biomed.uninet.edu/2012/n2/hernandez.html