%0 Journal Article %T Metal Toxicity at the Synapse: Presynaptic, Postsynaptic, and Long-Term Effects %A Sanah Sadiq %A Zena Ghazala %A Arnab Chowdhury %A Dietrich B¨¹sselberg %J Journal of Toxicology %D 2012 %I Hindawi Publishing Corporation %R 10.1155/2012/132671 %X Metal neurotoxicity is a global health concern. This paper summarizes the evidence for metal interactions with synaptic transmission and synaptic plasticity. Presynaptically metal ions modulate neurotransmitter release through their interaction with synaptic vesicles, ion channels, and the metabolism of neurotransmitters (NT). Many metals (e.g., 2 %U http://www.hindawi.com/journals/jt/2012/132671/