%0 Journal Article
%T Histoplasmose simulando neoplasia prim芍ria de pulm o ou met芍stases pulmonares Histoplasmosis mimicking primary lung cancer or pulmonary metastases
%A Aline Gehlen Dall Bello
%A Cecilia Bittencourt Severo
%A Luciana Silva Guazzelli
%A Flavio Mattos Oliveira
%J Jornal Brasileiro de Pneumologia
%D 2013
%I Sociedade Brasileira de Pneumologia e Tisiologia
%X OBJETIVO: Descrever as principais caracter赤sticas cl赤nico-radiol車gicas de pacientes com histoplasmose simulando cancer de pulm o. M谷TODOS: Estudo descritivo e retrospectivo baseado na an芍lise dos prontu芍rios m谷dicos de 294 pacientes diagnosticados com histoplasmose no Laborat車rio de Micologia da Irmandade Santa Casa de Miseric車rdia de Porto Alegre, em Porto Alegre (RS), entre 1977 e 2011. O diagn車stico de histoplasmose foi estabelecido por cultura, exame histopatol車gico ou identifica  o de bandas M ou H por imunodifus o. Ap車s identificar os pacientes com les es macrosc車picas e com achados compat赤veis de malignidade em radiografia ou TC de t車rax, os pacientes foram divididos em dois grupos: pacientes com hist車ria de cancer e les es simulando met芍stases (grupo HC) e pacientes sem hist車ria de cancer com les o simulando neoplasia prim芍ria (SHC). RESULTADOS: Dos 294 pacientes com histoplasmose, 15 apresentaram les es simulando neoplasia prim芍ria ou met芍stases (9 e 6 nos grupos HC e SHC, respectivamente). A idade dos pacientes variou de 13 a 67 anos (mediana, 44 anos) Dos 15 pacientes, 14 (93%) apresentaram les es pulmonares no momento da interna  o. CONCLUS ES: A s赤ndrome cl赤nica e radiol車gica da doen a neopl芍sica n o se limita a malignidade, e, portanto, as doen as infecciosas granulomatosas devem ser consideradas no diagn車stico diferencial. OBJECTIVE: To describe the main clinical and radiological characteristics of patients with histoplasmosis mimicking lung cancer. METHODS: This was a retrospective descriptive study based on the analysis of the medical records of the 294 patients diagnosed with histoplasmosis between 1977 and 2011 at the Mycology Laboratory of the Santa Casa Sisters of Mercy Hospital of Porto Alegre in the city of Porto Alegre, Brazil. The diagnosis of histoplasmosis was established by culture, histopathological examination, or immunodiffusion testing (identification of M or H precipitation bands). After identifying the patients with macroscopic lesions, as well as radiological and CT findings consistent with malignancy, we divided the patients into two groups: those with a history of cancer and presenting with lesions mimicking metastases (HC group); and those with no such history but also presenting with lesions mimicking metastases (NHC group). RESULTS: Of the 294 patients diagnosed with histoplasmosis, 15 had presented with lesions mimicking primary neoplasia or metastases (9 and 6 in the HC and NHC groups, respectively). The age of the patients ranged from 13 to 67 years (median, 44 years). Of the 15 patients, 14 (93%) presented wit
%K Histoplasmose
%K N車dulos pulmonares m迆ltiplos
%K N車dulo pulmonar solit芍rio
%K Histoplasmosis
%K Multiple pulmonary nodules
%K Solitary pulmonary nodule
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132013000100009