%0 Journal Article
%T Tenofovir therapy in chronic hepatitis B infection: 48-week results from Izmir Province, Turkey
%A £¿¨¹kran K£¿se
%A G¨¹rsel Ersan
%A S¨¹heyla Serin Senger
%A G¨¹ls¨¹n Ak£¿nc£¿o£¿lu
%J Journal of Microbiology and Infectious Diseases
%D 2012
%I Association of Health Investigations
%X Objectives: The goal of therapy in chronic hepatitis B infection (CHB) is to impede liver injury by suppressing viral replication.The study was aimed to determine the efficacy of tenofovir (TDF) in CHB infection for 48 weeks.Materials and methods: We retrospectively analyzed the data of 45 CHB patients treated by tenofovir. The patientswere divided into two groups based on their hepatitis B e antigen status (HBeAg). Those who were eligible to therapyreceived TDF 300 mg once daily for 48 weeks. Serum alanine aminotransferase levels (ALT), hepatitis B virus DNA (HBVDNA), and viral serological markers were checked at three-month intervals. Liver biopsy scores were determined in allpatients.Results: The mean age ¡À standard deviation (SD) was 35.8 ¡À 17.0 years, 26 (57.8 %) were male, and seven patients(15.5%) were treatment-experienced by a nucleos(t)ide analogue before TDF. HBeAg was positive in 17 (37.8%) patients.At week 48 among HBeAg positive (HBeAg +) patients¡¯ biochemical and virological response rates at month-3, -6 and-12 were 64.7%, and 100%, 70.6%, and 94.1%, and 88.2%, and 64.7%, respectively. The serological response in HBeAg+ patients was 29.4%. For HBeAg negative (HBeAg -) patients; biochemical, and virological response rates were 64.3%,and 96.4% at month 3; 82.1%, and 96.4% at month 6; and 100%, and 85.7% at month 12, respectively. At week 48 bothgroups had significant virological response (p<0.001).Conclusion: Treatment in CHB with TDF leads to HBV DNA suppression without evident resistance for 48-week, and iswell tolerated. J Microbiol Infect Dis 2012; 2(3): 87-92Key words: Hepatitis B, chronic, tenofovir disoproxil
%K Hepatitis B
%K chronic
%K tenofovir disoproxil
%U http://www.jcmid.org/upload/sayi/9/JMID-00603.pdf