%0 Journal Article
%T SYNTHESIS OF NEWER HETEROCYCLIC MOLECULES USING COMBINATION OF BENZIMIDAZOLE AND PYRAZOLE
%A Patel Ojas
%A Prajapati Paresh
%J Journal of Pharmaceutical and Scientific Innovation
%D 2013
%I Moksha Publishing House
%X Benzimidazole and pyrazole are heterocyclic compound that play crucial roles in the function of a number of biologically important molecules. Benzimidazole and pyrazole derivatives have shown different therapeutic properties such as antiulcer, antihelminthic, antihypertensive, anticoagulant, antiallergic, analgesic, anti-inflammatory, antimicrobial, antiviral, antiparasitic, antioxidant etc. As per the literature the by simple nucleophillic reaction we formed the 1-(1H-benzoimidazol-1-yl)-2-chloroethanone. Then addition reaction with hydrazine to give 2-(1H-benzo[d]imidazol-1-yl) acetohydrazide. After that we use ethylacetoacatate to give 1-(2-(1H-benzo[d]imidazol-1-yl) acetyl)-3-methyl-1H-pyrazol-5(4H)-one by cyclisation. Followed by addition of different aldehyde to give newer heterocyclic derivatives. These all newer compounds were characterized by IR, MASS and NMR spectroscopy.
%K Benzimidazole
%K Pyrazole
%K IR
%K MASS
%K NMR.
%U http://jpsionline.com/admin/php/uploads/172_pdf.pdf