%0 Journal Article
%T SYNTHESIS OF 4-[(4)5- IMIDAZOLYL] BENZOYL DERIVATIVES OF AMINO ACIDS AND PEPTIDES AS POTENT ANTHELMINTIC AGENTS
%A M. Himaja
%A Pragya Priyanka
%A Vinodhini V
%A Asif Karigar
%J Journal of Pharmaceutical and Scientific Innovation
%D 2012
%I Moksha Publishing House
%X A series of 4-[(4)5-imidazolyl] benzoic acids derivatives of amino acids and peptides were synthesized by reacting 4-[(4)5-imidazoyl benzoic acid with amino acids and dipeptides. The structures of the synthesized compounds were characterized by FTIR, 1H NMR, 13C NMR, and GC-MS data and the synthesized compounds were screened for their anthelmintic activity and the results showed that the compounds containing Ala-Ile and Pro-Val exhibited potent anthelmintic activity against Eudrillus Eugenia at that of standard Mebendazole a concentration of 100mg/50ml. The synthesized compounds were also studied for their insecticidal activity and they showed moderate to less insecticidal activity as compared to the standard drug Chloropyrifos.
%K Benzimidazole
%K Peptides
%K solution phase peptide synthesis
%K anthelmintic activity and insecticidal activity.
%U http://jpsionline.com/admin/php/uploads/136_pdf.pdf