%0 Journal Article
%T Effects of Citrus aurantifolia peel essential oil on serum cholesterol levels in Wistar rats
%A Parichehr Yaghmaie
%A Kazem Parivar
%A Minou Haftsavar
%J Journal of Paramedical Sciences
%D 2011
%I Shahid Beheshti University of Medical Sciences
%X The present study seeks to evaluate the effects of Citrus aurantifolia peel essential oil on serum triglyceride and cholesterols in Wistar rats. Thirty Wistar rats were divided into 5 groups: control, sham, and 3 experimental groups. The animals were treated in 2 phases: first, except for control group, which received normal saline, the rest of the groups were fed with a high cholesterol regimen to induce hyperlipidemia; then, the 3 experimental groups were treated with Citrus aurantifolia peel essential oil in 3 different doses: 25, 50, and 100   lit/kg. Results: The sham group demonstrated a significant rise in mean serum triglyceride, cholesterol, and LDL level in comparison with the control group (p<0.05) proving the effectiveness of hypercholesterolemia induction. The results of experimental groups treated with peel essential oil in 50 and 100   lit/kg doses demonstrated a significant reduction in triglyceride, cholesterol, and LDL (p< 0.01). Application of the peel essential oil of Citrus aurantifolia showed significant decrease of cholesterol in rats in doses 50 and 100   lit/kg. It is suggested that for cardiovascular risk reduction, the essential oil may be investigated for the same effects in human beings.
%K Hypercholesterolemia
%K Citrus Peel Extract
%K Lipid
%K Wistar Rat.
%U http://journals.sbmu.ac.ir/jps/article/view/2145/1833