%0 Journal Article
%T Spectrophotometric study of ¦Â-cyclodextrin-rosiglitazone maleate inclusion complex and its analytical application
%A Indresh Jain
%A Gulshan Bansal
%J Journal of Pharmaceutical Education and Research
%D 2010
%I Punjab College of Technical Education
%X A spectrophotometric method for accurate determination of rosiglitazone maleate (RGM)-¦Â-cyclodextrin (¦Â-CD)inclusion complex in aqueous solution was developed and validated. Host-guest complex (1:1) formed between ¦Â-CD and RGM was characterized through spectral analyses. The concentration of ¦Â-CD, pH of the medium,temperature and reaction time were optimized for maximum stability and absorbance of the complex. The method was found linear in the drug concentration range of 2.5-15.0 ¦Ìg/ml, precise (% RSD <1), sensitive (LOD 1.5 ¦Ìg/ml) and accurate (recoveries 98.50-100.6%). Finally, the method was applied successfully to thermal and photostability testing of RGM tablets.
%K Rosiglitazone maleate
%K ¦Â-cyclodextrin
%K inclusion complex
%K stability
%U http://www.pcte.edu.in/jper/issues/2010-june-vol-1-issue-1/paper-4.pdf