%0 Journal Article
%T Acinetobacter baumannii isolates in a tertiary care hospital: Antimicrobial resistance and clinical significance
%A Namita Jaggi
%A Pushpa Sissodia
%A Lalit Sharma
%J Journal of Microbiology and Infectious Diseases
%D 2012
%I Association of Health Investigations
%X Objectives: To carry out a retrospective study on Acinetobacter baumannii isolates from various clinical samples in a tertiary carehospital in India and analyze its epidemiology, antibiotic susceptibility patterns, pathogenic potential and nosocomial status.Materials and methods: The clinical specimens over a period of 14 months from December 2008 to January 2010 were analyzedand the A.baumannii isolates obtained by an automated identification system (Vitek 2 Compact) were segregated for furtherstudy. Their antibiograms were studied and a clinical correlation was made to assess their pathogenic status and mode of acquisition.Further, the nosocomial infections acquired during this period were studied and the contribution made by A.baumannii wascalculated to assess its nosocomial status.Results: A.baumannii was isolated in 155 samples out of 1632 gram negative isolates (9.4% prevalence) from the entire hospital.Maximum isolates were from respiratory secretions (57.4%) followed by blood (23.8%). Prevalence of A.baumannii rose to 22.7%(119 out of 525) in intensive care unit (ICU) and 65 isolates (54.6%) proved to be pathogenic. A.baumannii contributed to 30.4%ventilator associated pneumonia, 35.2% Catheter Associated Blood Stream Infections, 12.5% Surgical Site Infections and 2.94%Catheter Associated Urinary Tract Infections. Overall resistance of A.baumannii towards carbapenems was 90% from all hospitalisolates. ICU isolates showed higher resistance (93.2%) as compared to Inpatient Department (82.7%) and Out-patient Department(57.1%).Conclusion: In this study, A.baumannii isolates showed a pathogenic potential of around 54.6% and a majority were found to becarbapenem resistant. We must be cognizant of the fact that all A.baumannii isolations doesnĄ¯t necessarily mean infection andantibiotics should only be given in clinically proven infections. J Microbiol Infect Dis 2012; 2(2): 57-63Key words: A.baumannii; prevalence; resistance patterns; clinical correlation; nosocomial status
%K A.baumannii
%K prevalence
%K resistance patterns
%K clinical correlation
%K nosocomial status
%U http://www.jcmid.org/upload/sayi/8/JMID-00562.pdf