%0 Journal Article
%T Composition and biological significance of the human N¦Á-terminal acetyltransferases
%A Starheim Kristian K
%A Gromyko Darina
%A Velde Rolf
%A Varhaug Jan
%J BMC Proceedings
%D 2009
%I BioMed Central
%R 10.1186/1753-6561-3-s6-s3
%X Protein N¦Á-terminal acetylation is one of the most common protein modifications in eukaryotic cells, occurring on approximately 80% of soluble human proteins. An increasing number of studies links N¦Á-terminal acetylation to cell differentiation, cell cycle, cell survival, and cancer. Thus, N¦Á-terminal acetylation is an essential modification for normal cell function in humans. Still, little is known about the functional role of N¦Á-terminal acetylation. Recently, the three major human N-acetyltransferase complexes, hNatA, hNatB and hNatC, were identified and characterized. We here summarize the identified N-terminal acetyltransferase complexes in humans, and we review the biological studies on N¦Á-terminal acetylation in humans and other higher eukaryotes.
%U http://www.biomedcentral.com/content/pdf/1753-6561-3-S6-info.pdf