%0 Journal Article %T A randomized, open labeled, comparative study to assess the efficacy and safety of controller medications as add on to inhaled corticosteroid and long-acting ¦Â2 agonist in the treatment of moderate-to-severe persistent asthma %A Patel Y %A Patel P %A Bavadia H %A Dave J %J Journal of Postgraduate Medicine %D 2010 %I Medknow Publications %X Background : The goal of asthma therapy is to achieve clinical control and near normal lung functions. Many patients with persistent asthma fail to achieve this goal with a single controller medication add on to a inhaled corticosteroid. We have checked whether another controller medication add on to inhaled corticosteroid and long-acting ¦Â2 agonist helps in achieving the asthma goal or not. Objectives : To identify the effect of controller medication add on to inhaled corticosteroid and the long-acting ¦Â2 agonist on the clinical symptom, lung function, and compliance in patients with asthma. Materials and Methods : We conducted a randomized, open-labeled, comparative trial in 50 participants with moderate-to-severe persistent asthma. The study duration was of 10 weeks. During the first two weeks of the run-in period all the participants received a dry powder inhaler drug delivery of budesonide (400 mcg/day) and formoterol (12 mcg/day) combination. At the end of the run-in period the participants were randomly allocated into three groups: group A (n = 16) received oral montelukast (10 mg/day); group B (n = 17) received oral doxophylline (400 mg/day), and group C (n = 17) received inhaled budesonide (400 mcg) as add on to the above-mentioned drugs of the run-in period. The primary outcome was improvement in forced expiratory volume at 1 second (FEV 1 ). Results : All the participants of the three groups had significant improvement in FEV 1 (P < 0.001) and asthma symptoms at the end of 10 weeks. The mean increase in FEV 1 (% of predicted) from the baseline, in groups A, B, and C was: 24.6; 21.33, and 19.86%, respectively. Conclusions : All add on controller medications helped, with a significant improvement of lung functions and asthma symptoms. %K Asthma %K inhaled corticosteroid %K long-acting beta2 agonist %K montelukast sodium %K doxophylline %K add on therapy %U http://www.jpgmonline.com/article.asp?issn=0022-3859;year=2010;volume=56;issue=4;spage=270;epage=274;aulast=Patel