%0 Journal Article
%T Oral Bioavailability of Simvastatin Novel Formulation in Albino Rats
%A Singla.N
%A Gupta.G.D
%A Kohli.K
%A Jain
%J Journal of Pharmaceutical Science and Technology
%D 2009
%I 
%X The aim of this study was to compare the single dose oral bioavailability of two formulations of Simvastatin in albino rats. Plasma was analyzed for simvastatin using a sensitive, reproducible, accurate and validated LC-MS/MS method. Pharmacokinetic parameters including AUC0-t, AUC0-¡Þ, Cmax, Tmax, and t1/2 were determined from plasma concentration for both formulations. Self-emulsifying Formulation of simvastatin showed a significant improvement in bioavailability (1.5 fold) as compared with the conventional tablets.
%K Bioavailability
%K Pharmacokinetics
%K LC-MS/MS
%K Simvastatin
%U http://www.onlinepharmacytech.info/docs/vol1issue2/JPST09-01-02-07.pdf