%0 Journal Article
%T Design and Evaluation of Delayed and Extended Release Tablets of Mesalamine
%A NAGARAJU.R
%A SWAPNA.Y
%A HARI BABU.R
%A RAJESH KAZA
%J Journal of Pharmaceutical Science and Technology
%D 2010
%I 
%X The present study was focused on optimization of the formulation for the delayed and extendedrelease tablets of mesalamine. Various formulations was prepared by wet granulation technique usingthe polymers, such as HPMCK-100M, HPMC K4M, HPMCE15 and HPMC E5. It was found that the best formulation ML10 showed 98.75 % of drug release at the end of 10 th hour. This way the best formulation was achieved by using the combination of high and low viscous polymers HPMC K4M and HPMC E5 in the ratio of 60:40 was able to prolong the drug release for about 10 hrs in pH 7.5 phosphate buffer. In-vitro drug release studies of mesalamine delayed and extended release tablets showed that, the rate of the drug release follows first order kinetics as indicated straight line with good correlation coefficient for the plot of log percentage drug remaining vs time. The rate of drug release was found to be dissolution control as there was a good correlation coefficient for the plot of Hixon-Crowell cube¨Croot law.
%K Mesalmine
%K deayled
%K extended
%K tablets
%K kinetics
%K correlation coefficient
%U http://www.onlinepharmacytech.info/docs/vol2issue1/JPST10-02-01-03.pdf