%0 Journal Article
%T Chronic myeloid leukemia as a stem cell-derived malignancy
%A Sadegh Babashah
%A Mostafa Rezaei-Tavirani
%A Mona Zamanian-Azodi
%A Najmaldin saki
%J Journal of Paramedical Sciences
%D 2012
%I Shahid Beheshti University of Medical Sciences
%X Chronic myeloid leukemia (CML) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the Philadelphia (Ph) chromosome. Although imatinib inhibits the BCR-ABL kinase activity, clinical experiences confirm that imatinib may not target CML stem cells in vivo. The identification of signaling pathways responsible for the self-renewal properties of leukemic stem cells in CML will help in the discovery of novel therapeutic targets. Here we review signaling pathways including Wnt/¦Â-catenin, Hedgehog, Alox5, and Foxo which play crucial roles in the maintenance of stem cell functions in CML. It is thought that inhibition of key genes that are part of self-renewal associated signaling pathways may provide an effective way to reduce aberrant stem cell renewal in CML.
%K cancer stem cells
%K chronic myeloid leukemia stem cells
%K signaling pathway
%K microRNA
%U http://journals.sbmu.ac.ir/jps/article/view/3479/3123