%0 Journal Article
%T The Novel Therapeutic Approaches of Breast Cancer Treatment by Inhibition of DNA Damage Signaling Pathways in erbb2 Gene
%A Venkatesan Suba
%A Ravichandiran V
%A Arun Kumar Kuna
%A Ranga Mahendranath
%J Journal of Pharmaceutical Science and Technology
%D 2010
%I 
%X The term ¡°breast cancer¡± refers to a malignant tumor caused by a genetic abnormality in the breast cancer. An alarming increase in breast cancer cases, demands a renewed effort to seek effective treatment. In this paper we report the noval therapeutic approaches of breast cancer treatment by inhibition of DNA damage signaling pathways in erbB2 gene. Specific protein causing the disease is identified as erbB2. Homology modeling of the protein is done by using SPDBV (Swiss Protein Data Bank viewer). Active site analysis is done through a sitefinder method. Standard available market drugs targeting the protein were identified and similar molecules were docked using Argus lab for these standard molecules. A data is created with all these molecules in VegaZZ. Virtual screening of these molecules is done by protein database docking method. The result obtained showed that HEXADECANOATE is interacting at lowest energy level with more amino acids in the potential active site. So, it is considered that ligand as the potential lead molecule to target the protein in treatment of breastcancer.
%K erbB2
%K docking
%K drug design
%K offline tool
%K SPDBV.
%U http://www.onlinepharmacytech.info/docs/vol2issue11/JPST10-02-11-01.pdf