%0 Journal Article
%T Anticonvulsant Activity of Methanol Extract of Rhizomes of Cyperus tegetum Roxb.
%A Chaulya NC*
%A 1
%A Haldar PK2
%A Mukherjee A3
%A Khanra R1
%J Journal of PharmaSciTech
%D 2011
%I Trinity Trust
%X The present study was carried out to evaluate the anticonvulsant effect of methanol extract of Roxb (MECT) in Swiss albino mice. The anticonvulsant effect of methanol extract at a dose of 250, 500, 750 and 1000 mg/kg bw were examined against pentylenetetrazole (PTZ, 80 mg/kg IP) and isoniazide (INH, 300mg/kg p.o) induced seizures and significantly delayed the onset and also antagonized the seizures indose dependent manner. Diazepam (2 mg/kg IP) was used as reference standard. The methanol extract at a dose of 1000 mg/kg IP produced66.66% protection in mice against PTZ-induced convulsion in mice and at a dose of 750 mg/kg IP of the extract produced 83.34% protectionagainst INH-induced convulsion in mice. The results obtained from this study indicate that the methanol extract of rhizome of may bebeneficial in both tonic and clonic seizures.
%K Cyperus tegetum
%K anticonvulsant
%K pentelentetrazole
%K isoniazide
%U http://www.pharmascitech.in/admin/php/uploads/1_pdf.pdf