%0 Journal Article
%T 重组人血管内皮抑素联合放疗对肺腺癌A549细胞TGF-β1、HIF-1α表达的影响<br>Effect of Recombinant Endostatin in Combination with Radiotherapy on the Expression of TGF-β1 and HIF-1α in Lung Adenocarcinoma Cell A549
%A 介芳芳
%A 曹德东
%A 戈伟
%A 徐细明
%A 李长虎
%A 杨芳
%A 黄玉
%A 刘梁
%A 郑永法
%J Asian Case Reports in Oncology
%P 5-10
%@ 2169-883X
%D 2012
%I Hans Publishing
%R 10.12677/ACRPO.2012.12002
%X <p>
	<div style=\"text-align:justify;\">
		<span style=\"line-height:1.5;\">通过观察</span><span style=\"line-height:1.5;\">Endostar</span><span style=\"line-height:1.5;\">联合放疗对肺腺癌</span><span style=\"line-height:1.5;\">A549</span><span style=\"line-height:1.5;\">细胞增值及</span><span style=\"line-height:1.5;\">TGF-</span><span style=\"line-height:1.5;\">β</span><span style=\"line-height:1.5;\">1</span><span style=\"line-height:1.5;\">、</span><span style=\"line-height:1.5;\">HIF-1</span><span style=\"line-height:1.5;\">α</span><span style=\"line-height:1.5;\">表达的影响，初步探讨重组血管内皮抑素的放疗增敏机制。</span><span style=\"line-height:1.5;\">方法：</span><span style=\"line-height:1.5;\">将培养至对数生长期的</span><span style=\"line-height:1.5;\">A549</span><span style=\"line-height:1.5;\">细胞分为对照组、单纯放疗组、恩度组、联合组，检测各组</span><span style=\"line-height:1.5;\">A549</span><span style=\"line-height:1.5;\">细胞增殖率及</span><span style=\"line-height:1.5;\">TGF-</span><span style=\"line-height:1.5;\">β</span><span style=\"line-height:1.5;\">1</span><span style=\"line-height:1.5;\">、</span><span style=\"line-height:1.5;\">HIF-1</span><span style=\"line-height:1.5;\">α</span><span style=\"line-height:1.5;\">蛋白和</span><span style=\"line-height:1.5;\">mRNA</span><span style=\"line-height:1.5;\">表达情况。</span><span style=\"line-height:1.5;\">结果：</span><span style=\"line-height:1.5;\">1</span><span style=\"line-height:1.5;\">) </span><span style=\"line-height:1.5;\">除对照组外，</span><span style=\"line-height:1.5;\">各组细胞的增殖随时间的改变都受到不同程度的抑制，以联合组最为明显，差异具有统计学意义</span><span style=\"line-height:1.5;\">(</span><span style=\"line-height:1.5;\">p </span><span style=\"line-height:1.5;\">&lt; 0.05)</span><span style=\"line-height:1.5;\">；</span><span style=\"line-height:1.5;\">2) </span><span style=\"line-height:1.5;\">处理后各组</span><span style=\"line-height:1.5;\">A549</span><span style=\"line-height:1.5;\">细胞</span><span style=\"line-height:1.5;\">TGF-</span><span style=\"line-height:1.5;\">β</span><span style=\"line-height:1.5;\">1</span><span style=\"line-height:1.5;\">、</span><span style=\"line-height:1.5;\">HIF-1</span><span style=\"line-height:1.5;\">α</span><span style=\"line-height:1.5;\">的分泌下降，</span><span style=\"line-height:1.5;\">24 h</span><span style=\"line-height:1.5;\">以放疗组及联合组</span><span style=\"line-height:1.5;\">TGF-</span><span style=\"line-height:1.5;\">β</span><span style=\"line-height:1.5;\">1</span><span style=\"line-height:1.5;\">、</span><span style=\"line-height:1.5;\">HIF-1</span><span style=\"line-height:1.5;\">α</span><span style=\"line-height:1.5;\">表达量明显下降</span><span style=\"line-height:1.5;\">
%K 重组人血管内皮抑素；放射治疗；转化生长因子-β1；乏氧诱导因子-1α；肺腺癌<br>Endostar
%K Radiotherapy
%K Transforming Growth Factor-Beta 1
%K Hypoxia Induced Factor-1α
%K Lung Adenocarcinoma
%U http://www.hanspub.org/journal/PaperInformation.aspx?PaperID=5024