%0 Journal Article
%T The Effects of Dietary Omega-3 Fatty Acid Supplementation on Inflammatory Biomarkers in Type-2 Diabetic Patients
%A Ali Malekshahi Moghadam
%A Ahmad Saedisomeolia
%A Mahmoud Djalali
%A Fereshteh Sojoudi
%J Journal of School of Public Health and Institute of Public Health Research
%D 2012
%I 
%X Background and Aim: Omega-3 fatty acids can reduce inflammation in diabetic patients via special mechanisms. The objective the current study was to investigate the effects dietary omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor-alpha (TNF-¦Á) in type 2 diabetes patients. Materials and Methods: This randomized double-blind placebo-controlled clinical trial was conducted on 57 subjects with type-2 diabetes. The participants were randomly assigned to one of 2 groups receiving either an omega-3 fatty acid supplement (containing 1584 mg eicosapentaenoic acid, 828 mg docosahexaenoic acid, and 338 mg other omega-3 fatty acids) or a placebo tablet (containing 2100 mg sunflower oil) for a period of 8 weeks.Results: The serum TNF-&alpha and IL-2 concentrations decreased significantly in the omega-3 fatty acid group in comparison with the placebo group (in both cases, p<0.01). The intervention did not bring about any statistically significant changes in the serum CRP concentrations. Conclusion: Considering the beneficial effects of omega-3 dietary fatty acid supplements on the 2 inflammatory biomarkers, namely TNF-¦Á and IL-2, type-2 diabetes patients are recommended to consume such supplements or foodstuffs rich in omega-3 fatty acids, e.g., fish.
%K Omega-3 Fatty Acid
%K Type-2 Diabetes
%K CRP
%K TNF-¦Á
%K IL-2
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20445.pdf&manuscript_id=20445